聚晶制粒技术的研究进展

申瑞芳,,单利,高春生*

中国药学杂志 ›› 2014, Vol. 49 ›› Issue (17) : 1481-1485.

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中国药学杂志 ›› 2014, Vol. 49 ›› Issue (17) : 1481-1485. DOI: 10.11669/cpj.2014.17.001
综 述

聚晶制粒技术的研究进展

  • 申瑞芳1,2,单利1,高春生1*
作者信息 +

Advance on Crystallo-co-Agglomeration Based Particle Engineering Technique

  • SHEN Rui-fang1,2, SHAN Li1, GAO Chun-sheng1*
Author information +
文章历史 +

摘要

目的 介绍聚晶制粒技术制备药物微粒的研究进展。方法 以近年来的研究文献为基础,对聚晶制粒技术的原理、制备过程、影响因素、质量评价、最新进展和发展趋势等方面进行归纳总结。结果与结论 与球晶技术相比,聚晶制粒技术在制备药物微粒上有自身的特色,具有发展潜力和应用前景。

Abstract

OBJECTIVE To introduce the crystallo-co-agglomeration (CCA) approach and its recent pharmaceutical progress. METHODS The forming mechanism, the manufacturing process, the evaluation parameter and the current trends of the CCA-based particle engineering technique have been summarized based on the literature at home and abroad. RESUTLS AND CONCLUSION Compared to the spherical crystallization, the CCA have definite advantages thus develop rapidly in recent years.

关键词

聚晶制粒 / 球晶 / 直接压片 / 多元微粒药物传输系统

Key words

crystallo-co-agglomeration / spherical crystallization / direct compression / multiple units particulate drug delivery system

引用本文

导出引用
申瑞芳,,单利,高春生*. 聚晶制粒技术的研究进展[J]. 中国药学杂志, 2014, 49(17): 1481-1485 https://doi.org/10.11669/cpj.2014.17.001
SHEN Rui-fang,, SHAN Li, GAO Chun-sheng*. Advance on Crystallo-co-Agglomeration Based Particle Engineering Technique[J]. Chinese Pharmaceutical Journal, 2014, 49(17): 1481-1485 https://doi.org/10.11669/cpj.2014.17.001
中图分类号: R944   

参考文献

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基金

国家科技重大专项——综合性新药研究开发技术大平台资助项目(2012ZX09301003-001)
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